Automated force spectroscopy for single molecules The Bruker JPK ForceRobot 300 is a fully automated force spectroscope for studying molecular interactions at the nanoscale. It’s a label-free, sensitive technique – characterise the unfolding forces of single proteins and molecular bonds. Single molecule force spectroscopy has traditionally been laborious and complex. By automating alignment, calibration and routine procedures, the procedure does not require as much of your attention, with considerably improved data output.ForceRobot 300
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Force spectroscopy curve of ddFLN filamin unfolding, with WLC fits including contour length, persistence length, fit quality, breaking force and loading rate. Multiple events are automatically recognised, fit and generated for export using batch processing. Courtesy or M.Rief, TU München.
Faster Force Spectroscopy
To interpret force spectroscopy data, you need a large number of reproducible data sets. ForceRobot speeds up this process and makes it a much more practical, viable technique for your lab.
Routine procedures are automated, with intelligent software for experiment design, data acquisition and evaluation. Tens of thousands of force curves can be generated in a matter of hours, while the system runs attended – saving you time. Force curves without events are filtered out automatically before processing.
Data Quality
As a dedicated system, the JPK ForceRobot has features to provide you with as much data as possible, with the highest quality:
- Low electronic noise floor
- Rigid mechanical design
- High accuracy and stability, with integrated capacitive position sensors
- Symmetric design to minimise drift
- High sensitivity and detection bandwidth to detect small variations in force curves
- High sampling rate and virtually unlimited data points per curve
Recognition map on a protein-covered surface,
