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Bruker Micro-TXRF

The Bruker S2 PICOFOX is a fast TXRF trace element analysis system. It’s the world’s first portable benchtop spectrometer for fast quantitative and semi-quantitative multi-element microanalysis of liquids, suspensions, solids and contaminations using Total Reflection X-ray Fluorescence Spectroscopy.


Detect trace elements

Down to ppb and ppm range, with simultaneous multi-element analysis.

Only a small quantity of sample required

Faster and easier than ICP-MS

Easier sample preparation, with a CO2 footprint about 10 times lower.

Low running costs

No consumables, gas or liquid nitrogen


TXRF is a highly sensitive technique for trace element analysis, with detection limits in the ppb and ppm range. The S2 PICOFOX is particularly suited to working with very small sample quantities, liquids with high matrix content and research involving different types of samples.

No cooling medium is required, so the analyser can be used not only in the laboratory but also in the field.


  • Simultaneous multi-element trace analysis inc. halogenides
  • Analyse small sample amounts in the nanogram or microgram range
  • Simple quantification using an internal standard
  • Extremely flexible – analyse a wide variety of sample types
  • Use in the lab or on-site in the field
  • No matrix or memory effects
  • Low running costs – no consumables or maintenance
  • Alternative to ICP-MS – easier sample preparation and shorter sampling time


Nanoparticle analysis


Materials such as nanoparticles are used in the production of industrial and consumer products. Ongoing product development accompanied by increasing concerns about the impact on human health and the environment has lead to a growing demand for versatile analytical technologies. In this example, the S2 PICOFOX was used to analyse element ratios in CdSe nanoparticles coated with ZnS.

 Read the lab report…

Pharmaceutical Authenticity Testing

Pharmaceutical Authenticity Testing

Characterisation of brand drugs and their generics is an essential task in pharmaceutical analysis. Alternative methods such as AAS and ICP-OES are restricted by sample quantity, sample digestion and matrix-related difficulties. TXRF can analyse samples in the microgram range. With internal standardisation, no standards for external calibration are required.

Life science TXRF

Life Science

  • Trace elements in biological matrices and their impact in clinical chemistry.
Milk powder quality control

Quality Control of Liquid Nutrients and Milk Powder

Take quantitative measurements of macro- and micro- nutrients. Liquid samples can be analysed directly, and powders need only be suspended in a detergent. Detection limits for micro-nutrients in milk and liquid nutritional products are below 300 ppb.

Other Food Applications

  • Rapid screening for nutrition-relevant elements in fish – read the lab report…
  • Trace element analysis of plant material – read the lab report…
    • Detection of toxic elements
    • Control of essential macro and trace elements for nutrition and fertilisation control of agricultural plants
    • Pesticide and adulterate detection
  • Analysis of lead in tea drinks – read the lab report…
  • Ultra trace analysis of arsenic in rice – more details…
  • Analysis of red and white wines – more details…
Forensics bullet analysis


  • Forensic distance determination after firearm use.
  • Other forensics applications, including characterisation of glass fragments – contact us for details.

Mercury traces in glass

Mercury in Glass

The use of mercury is essential in the lighting industry, although it is a hazardous element. In production and recycling, it is vital to control mercury levels. Due to its high volatility at room temperature, trace analysis of mercury can be complicated. Common methods such as Cold Vapor Atomic Absorption Spectroscopy (CV AAS) are time consuming and cost intensive. TXRF sample preparation is much faster, simpler and does not require acids. The technique also used internal calibration, so no solutions for external calibration need to be prepared.

Water analysis with TXRF




Media Gallery

Nutrients, Additives, and Contaminants in Food, Feed, Supplements and Beverages

How portable and benchtop XRF spectrometers are used to quickly analayse food samples and beverages, with easy sample preparation for both liquids and solids – no laborious digestion procedures or hazardous chemicals.

On-demand webinar

On-site Trace Element Analysis of Wastewater, Sewage and Industrial Effluents

Trace element analysis of industrial wastewater, sewage, mining waste and process run-off. TXRF has easy sample preparation for routine lab analysis, industrial lab testing and environmental research institutions. Learn about the preparation of slurries, suspensions and other multi-phase mixtures without any time-consuming digestion procedures.

On-demand webinar

TXRF Analysis of Biological and Medical Samples

One hour webinar about TXRF in medical and biological research, including micro-nutrient distribution and toxic metals in hair.

On-demand webinar

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