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BioContinuum HD

The Gatan BioContinuum HD is a TEM imaging filter for cryo-EM with optional EELS and EFTEM capabilities.

It’s only full-featured, post-column imaging and energy filter available. The BioContinuum HD delivers zero-loss filtering to improve the contrast of TEM images for both life and material science, and can also acquire EELS and EFTEM data.


Based on best-in-class technology

Combines Gatan’s GIF electron optics, K3 camera and world-class software.

Optional EELS and EFTEM

As well as cryo-EM, cryo-ET and low-dose STEM spectrum imaging.

Easy to use

Straightforward software, and auto tuning and alignment.

Stable optics

Consistent data quality without downtime.


The new Gatan BioContinuum HD provides zero-loss filtering to improve the contrast of TEM images in both life and material science applications. There’s also the option to add features for acquiring EELS (Electron Energy Loss Spectroscopy) and EFTEM (Energy-Filtered Transmission Electron Microscopy) data.


The BioContinuum HD imaging filter is compatible with most TEMs from Thermo Fisher, JEOL and Hitachi.

It combines with Gatan’s Microscopy Suite software including DigitalMicrograph, STEMPack spectrum imaging, Latitude S, Latitude T and Latitude D.

You can also use Thermo Scientific EPU software, Thermo Scientific Tomography software, Serial EM and Leginion for traditional life science data collection.

Combining Established Technologies

The BioContinuum HD incorporates several powerful technologies from Gatan:

  • Latest generation GIF electron optics.
  • K3 camera with direct detection technology.
  • World-class EELS and EFTEM acquisition and analysis software.


The BioContinuum HD is optimised for:

  • Cryo-EM (cryo-electron microscopy)
  • Cryo-ET (cryo-electron tomography)
  • Low-dose STEM spectrum imaging
  • EELS

Gain insights into the atomic structure of biological macromolecules and disease progression at the molecular level, and broaden your research to applications at the convergence of life and material science.

Stable Optics

Gatan offers the most stable optics available. ZLP positioning delivers consistent data quality without downtime.

Cutting-edge aberration correction reduces image and energy distortion for uniform imaging over the entire field of view.

High Quality Direct Detection Imaging

  • Highest DQE and widest operating voltage range: Acquire data at the highest resolutions from 80 – 300 kV.
  • Fast data collection at >600 movies per hour.
  • Large field of view: Ideal for single particle analysis and understanding the wider biological context in cryo-ET.

Easy to Use

Gatan’s DigitalMicrograph, Latitude and AutoFilter software is straightforward and easy to use, while still giving you full power and flexibility.

Tuning and alignment are performed with one button, using smart algorithms. This speeds up the process and makes optics alignment a much simpler process.


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